Project #583

Project #583 - Trophos - France

Date: 2009/07/22

Deadline: 2010/07/01

Contact

Organisation	Trophos	Department
Contact person	Veys, Mr Julien
Email	jveys@trophos.com
Address	Parc Scientifique de Luminy Case 931
Postcode	13288	City	Marseille cedex 09
Country	France
Telephone	+33491828282	Fax
Website	www.trophos.com

Familiar with the European Framework Programme? NO

PROJECT

Title: Comparison of mitochondrial targeted therapeutic approaches to prevent ischemia-reperfusion injury to the heart: new clinical paradigms to inform improved pre-clinical models

Acronym: CoMiTTIRI

Project type	Small or medium-scale focused research collaborative project
Status	Planned for submission
Call references	Others

Priorities’ Main Research Areas	The main objectives of the project will be 1/ to assess the efficacy of up to three new mitochondrial targeted therapeutic approaches to reduce infarct size in an ischemia/reperfusion setting 2/ to collect patients’ data that would enable in the future both further understanding of the pathophysiology and better clinical trials design and 3/ to analyze efficacy and mechanisms in animal models compared to humans in order to refine and improve predictivity of preclinical models.
Workprogramme Topic (according to each priority workprogramme)
Project description The proposed project consists in a proof of concept clinical trial  that aims to further demonstrate the clinical relevance of the mitochondrial targeted therapeutic approach for the prevention of reperfusion injury. Should this approach be proven successful, it would therefore be a further step toward the approval of a new treatment paradigm that would significantly improve prognosis and quality of life of patients with acute myocardial infarction. Positive clinical trial results with any of these approaches will provide “validated targets” that can be expected to motivate industry investment to discover and develop therapies for cardiac ischemia-reperfusion injury, a serious but neglected medical need. In addition samples and data collected during the trial will allow an in depth analysis of the reasons of the success or failure of the trial.
Keywords	clinical trial, myocardial ischemia reperfusion injury, percutaneaous transluminal coronay angioplasty intervention, PTCA, therapeutic, diagnostic, imaging
Partners already involved
Project budget (for the running projects)	nc	Budget reserved for SMEs	nc

Research topics

• HEALTH.2010.2.4.2-2: New approaches to reduce ischemic damage to the heart.

Profile of SME sought

Role	technology development, research, demonstration
Country /region	none specified
Start of partnership	start-up phase
Expertise required	We are currently looking for a diagnostic or imaging company working in the field of myocardial infarction and more specifically myocardial reperfusion injury. The company should be developing new methods that would allow to assess functional protection or recovery of the myocardium. We are also looking for a company which would be able to collect and manage patients samples (biobank) meeting all quality and ethical standards. The company should also be able to develop new tools facilitating the identification and validation of relevant biomarkers of the disease using the above mentionned patients samples.